On the corner of Main and (I think it's) 7th Ave is one of the most awesome... well... billboards in the city. I hesitate to call it a billboard because it's so classic looking, it's been there for as long as I can remember and it's actually painted onto the side of the building.
When I first re-noticed it a few years back it was looking a little shabby, like it was in need of a paint job or that it might be slowly on it's way out because it was a standing relic from the past, like a bunch of the ghosts of signage that can be spotted on some brick buildings in Gastown. But it keeps getting refreshed and a quick internet search will tell you that is, in fact, a fully operational (likely thriving) business so the ad is still totally relevant. Should I ever drop a sum of cash on a fishing lodge excursion these guys are on the top of my list simply due to the awesomeness of this sign.